The best Anti-Virus/Anti-Ad Software

I have a real doozy of a spyware earlier tonight. It disabled my task manager, it closes my internet whenever I typed "virus" or "scan" in anything (yes, it nearly froze as I typed those words), and Ad Aware constantly freezes when it scans for things. My monitor will get staticy, my homepage changes....basically it's a whole lot of shit.

So I downloaded a french antivirus software from mininova. It helped a lot, but only temporary. The crap is still in my windows folder, and there's still a lot of spyware detected. So I need your opinion on what the best anti-virus/anti-spyware program there is, so I can fix this mess and be safe from any future infestations. I could really use your help here.

Jam it back in, in the dark.