Man, I've been playing RE4 lately
1) I'm not too hot with FPS games, so it takes me a while to make the transition. I've been playing South Park on N64 (emu) lately as well and there's no sensitivity setting so that's balls, so I'm still pretty useless at that.
Despite 2) using a PS2 controller set up similar to Turok: Evolution which I finished weeks ago. I change if I can, though I had to adapt to Turok: Evolution because of the lack of settings.
3) I keep going, it's usually the analogue sensitivity I struggle with, buttons take about half an hour to settle in.
Oh yeah, troubles with switching between Suikoden and FF games.
Jam it back in, in the dark.