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There is a difference between your brain shutting down out of depression and despair and the actual chemical makeup of your body changing because you're lonely. And we're not just talking about different seratonin levels or increased liver function or whatever, entire bodily systems are drastically altered.
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What regulates the chemical make-up and body functions, Mikey? The brain!
The only difference here is the amount of time either example takes. Its the same idea, only with different words used.
How ya doing, buddy?