Final Fantasy 13 been waiting since it first came out to get it
Super Mario Galaxy 2 I heard the game will be very challenging but as long as its not challenging at the beginning of the game then I'm fine with it

I'd say the biggest ones for me have already come out. Mass Effect 2, FF XIII, Bad Company 2, Assassins Creed 2 to name a few.

The only one I can think of is Starcraft 2, but after playing the beta, I kinda lost interest.

Adding 2 more games:

Assassin's Creed: Brotherhood and BlazBlue: Continuum Shift.